WebThis finding prompted us to examine whether apoE is a ligand for LRP4 in the rat brain. ApoE and LRP4 from both Cos7 cells heterologous expressing LRP4 and brain homogenate were co-immunoprecipitated. We then examined the effect of antibody against the ligand-binding domain of LRP4 (anti-LB). Anti-LB applied to neuronal cells in culture down ... WebOct 28, 2014 · We applied this method to the design of a specificity switch in the interface between the PDZ domain of α1-Syntrophin (hereafter referred to as Syntrophin) and the PDZ domain of neuronal nitric oxide synthase (nNOS), which serves as a ligand of Syntrophin. The nNOS PDZ domain forms a pseudopeptide and docks into the PDZ …
Hippocampal nuclear factor kappa B accounts for stress-induced
WebPDZ domains can also self- or heterodimerize, giving rise to large protein complexes. The PDZ domain of nNOS is composed of the core, or canonical, PDZ domain located at … WebCAPON may affect nNOS by modulating its ability to associate with PSD95/NMDA receptor complex. The coding variation of the NOS1AP gene may increase the susceptibility to mental diseases, such as schizophrenia, autism spectrum disorders (ASDs) and obsessive-compulsive disorder (OCD). ... Carboxyl-terminal PDZ ligand of neuronal nitric oxide ... describe the renal system
Protein Kinase D Interacts with Neuronal Nitric Oxide …
WebThis requires the C-terminal Class II-type PDZ ligand motif " IAV " because an equal amount of NOS1AP-IAV, in which the motif is deleted, is not pulled down. The motif does … WebApr 30, 2024 · However, NMDARs activation also induces the association of neuronal nitric oxide synthase (nNOS) with its carboxy-terminal PDZ ligand (CAPON), an event causing ERK dysfunction through S ... WebAug 27, 2014 · The PDZ ligand-binding pocket of nNOS is clearly separate from the beta-finger ligand of nNOS that binds PSD95 (Figure 2), and docking of ligand in the pocket itself was reported not to affect the beta … describe the results of a chemical change