High-affinity choline transporter 1
Web1 de jan. de 2024 · The high-affinity choline transporter was first cloned in 2000 and designated as CHT1 (Okuda et al. 2000 ). Structure and Functional Properties of CHT1 CHT1 is a member of the solute carrier family 5 (SLC5, sodium/glucose cotransporter family) and is also known as SLC5A7. It shares 20–25% amino acid sequence homology with … WebThe Na(+)-dependent uptake of choline by CHT1 is the rate-limiting step for synthesis of acetylcholine. CHT1 is the integral membrane protein with 13 transmembrane segments, …
High-affinity choline transporter 1
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WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay … Web3 de nov. de 2000 · Na +-dependent, high-affinity choline uptake in cholinergic neurons is the rate-limiting step in acetylcholine synthesis.Here we report the molecular cloning and …
Web18 de jan. de 2010 · The cho-1 gene in Caenorhabditis elegans encodes a high-affinity plasma-membrane choline transporter believed to be rate limiting for acetylcholine (ACh) synthesis in cholinergic nerve terminals. Web3 de nov. de 2000 · The presence of the high-affinity choline transporter Choline transporter 1 in nerve fibers and epithelial cells in the human and rat skin supporting the …
WebDownload Zoom Anti-Choline Transporter Antibody, high affinity detects level of Choline Transporter & has been published & validated for use in IH & WB. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References WebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the Caenorhabditis …
Web1 de out. de 2014 · The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and… Expand 15 PDF Competitive inhibition of the high-affinity choline transporter by tetrahydropyrimidine anthelmintics.
Web1 de mar. de 2007 · Cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT). In the present study we demonstrate putative cholinergic nerves in the rat heart using an antibody to ChAT of a peripheral type … birchgrove nsw mapWeb10 de jun. de 2005 · Maintenance of acetylcholine synthesis depends on the effective functioning of a high-affinity sodium-dependent choline transporter (CHT1). Recent studies have shown that this transporter is predominantly localized inside the cell, unlike other neurotransmitter transporters, suggesting that the trafficking of CHT1 to and from … birch grove nursery warringtonWeb8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the … birch grove nursing homeWeb22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a high affinity for choline. The second is organic cationic transporters OCT1 and OCT2 that have low affinity for choline, which recognize many cationic substances, and are mainly … birch grove nurseryWeb1 de jan. de 2005 · Kus, L. et al. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. J. Comp. Neurol. 463, 341–357 (2003). birch grove northfield njWebCHT1 is a member of the SLC5 family of solute transporters and is assigned to SLC5A7 ( 12. ). Its amino acid sequence has 20–25% homology with that of other members of this family ( 13. ). It has been assumed that all members of the family possess a common 13-transmembrane domain core ( 14. dallas direct flights to memphisWeb5 de mai. de 2024 · To examine the action of tetrahydropyrimidines on the nematode high-affinity choline transporter, we generated HEK293 cell lines stably expressing the high-affinity choline transporter from C. elegans (CHO-1), the ortholog of CHT1 (Okuda et al., 2000), and measured the high-affinity choline uptake activity in the presence of … birchgrove nsw postcode