S0859 is a selective, high-affinity generic Na+/HCO3- transporter ( NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (K =1.7 μM, full inhibition at approximately 30 μM). For research use only. We do not sell to patients. S0859 Chemical Structure CAS No. : 1019331-10-2 Get it tomorrow March 7 by noon. Web本发明公开了s0859在制备治疗脑缺血再灌注损伤药物中的应用。本发明以沙鼠双侧颈总动脉模型为实验对象,考察了s0859在脑缺血再灌注损伤药物中的作用。结果显示,s0859可改善脑缺血再灌注损伤后的神经功能缺失,动物狂躁及焦虑样行为,减少延迟性神经元细胞凋亡,可以通过降低akt的磷酸化水平 ...
S0859 ≥98% (HPLC) 1019331-10-2
WebSep 5, 2015 · S0859 (provided by Sanofi, Frankfurt-Höchst, Germany) was dissolved in dimethyl sulfoxide (DMSO) at a final DMSO concentration of max. 0.1%. The transport activity of NBCe1 was monitored in voltage-clamp mode, recording the change in holding current. As substrate, 5% CO 2 /24 mM HCO 3− was applied (at pH 7.4). WebSep 5, 2015 · S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart Br. J. Pharmacol. (2008) I. Choiet al. An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel Nature (2000) I. Choiet al. Cloning and characterization of a human electrogenic Na+–HCO3−cotransporter isoform (hhNBC) … barossa nursery
S0859 = 98 HPLC 1019331-10-2 - Sigma-Aldrich
WebS0859 is a selective high-affinity generic inhibitor of the Na + /HCO3-sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na +-H + exchange (NHE). Safety Information. Hazard Statements. H413. Precautionary Statements. P273 - P501. Hazard Classifications. Aquatic Chronic 4. Storage Class Code. WebS0859, an N-cyanosulphonamide compound, reversibly inhibited NBC-mediated pH (i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na (+)-coupled HCO (3) (-) transporters (NBCs) mediate the … WebMay 30, 2024 · We report herein that the electrogenic, sodium-dependent, bicarbonate cotransporter, SLC4A4, is expressed in the basolateral membrane of human and mouse airways, and that it’s pharmacological inhibition or … barossa merlot